SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
American Journal of Lifestyle Medicine
This Article
Right arrow Abstract Freely available
Right arrow Free Full Text (Free PDF) Free
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Andon, M. B.
Right arrow Articles by Anderson, J. W.
Right arrow Search for Related Content
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Reviews

State of the Art Reviews: The Oatmeal-Cholesterol Connection: 10 Years Later

Mark B. Andon, PhD

Quaker-Tropicana-Gatorade Research and Development Department, Barrington, Illinois, mark.andon{at}tropicana.com

James W. Anderson, MD

College of Medicine, Departments of Internal Medicine and Clinical Nutrition, University of Kentucky, Lexington

Ten years have passed since the Food and Drug Administration (FDA) completed their review of the literature pertaining to the consumption of whole-oat sources of soluble fiber and a reduction in blood cholesterol concentrations. Since that time, data have continued to accumulate regarding oat-soluble fiber consumption, cholesterol, and other physiologic vectors related to cardiovascular health. The objective of this review was to compare the findings of more contemporary analyses of the oat and cholesterol-reduction literature to determine if newer information is consistent with the original conclusion reached by the FDA. A number of formal assessments have been conducted subsequent to the FDA review, and virtually all have reached the same conclusion, namely, consumption of oats and oat-based products significantly reduces total cholesterol and low-density lipoprotein cholesterol concentrations without adverse effects on high-density lipoprotein cholesterol or triglyceride concentrations. In addition, a number of new insights about the potential benefits of oats have emerged over the past 10 years. These more recent data indicate that including oats and oat-based products as part of a lifestyle management program may confer health benefits that extend beyond total cholesterol and low-density lipoprotein cholesterol reduction.

Key Words: cholesterol • oats • heart disease • soluble fiber • CHD • CVD

References

  • US Department of Health and Human Services, Food and Drug Administration. Health claims: oats and coronary heart disease—proposed rule. Fed Regist. 1996;61:296-337.
  • US Department of Health and Human Services, Food and Drug Administration. Health claims: oats and coronary heart disease—final rule. Fed Regist. 1997;62:3583-3601.
  • US Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Special Nutritionals. Guidance for industry: significant scientific agreement in the review of health claims for conventional foods and dietary supplements, December 22, 1999. http://www.cfsan.fda.gov/~dms/ssaguide.html. Accessed May 7, 2007.
  • Brown L., Rosner B., Willett WW, Sacks FM Cholesterol-lowering effects of dietary fiber: a meta-analysis. Am J Clin Nutr. 1999;69:30-42.[Abstract/Free Full Text]
  • National Institutes of Health. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). NIH Pub. No. 02-5215. Washington, DC: National Institutes of Health; 2002.
  • Jenkins DJ, Kendall CW, Faulkner D., et al. A dietary portfolio approach to cholesterol reduction: combined effects of plant sterols, vegetable proteins, and viscous fibers in hypercholesterolemia. Metabolism. 2002;51:1596-1604.[CrossRef][Medline] [Order article via Infotrieve]
  • Theuwissen E., Mensink RP Simultaneous intake of beta-glucan and plant stanol esters affects lipid metabolism in slightly hypercholesterolemic subjects. J Nutr. 2007;137:583-588.[Abstract/Free Full Text]
  • Ministry of Health Malaysia. Guide to Nutrition Labelling and Claims. Putrajaya, Malaysia: Food Safety and Quality Division Ministry of Health Malaysia; 2006. http://www.moh.gov.my/MohPortal/. Accessed June 29, 2007.
  • Joint Health Claims Initiative. Final report on a generic health claim for oats and reduction of blood cholesterol. http://www.jhci.org.uk/. Accessed July 5, 2007.
  • Kelly SAM, Summerbell CD, Brynes A., Whittaker V., Frost G. Wholegrain cereals for coronary heart disease. Cochrane Database Syst Rev. 2007;2:CD005051. http://www.3.interscience.wiley.com/cgibin/mrwhome/106568753/HOME. Accessed July 8, 2007.[Medline] [Order article via Infotrieve]
  • Davidson MH, Dugan LD, Burns JH, Bova J., Story K., Drennan KB The hypocholesterolemic effects of beta-glucan in oatmeal and oat bran. JAMA. 1991;265:1833-1839.[Abstract/Free Full Text]
  • Van Horn L., Emidy LA, Liu K., et al. Serum lipid response to a fat-modified, oatmeal-enhanced diet. Prev Med. 1988;17:377-386.[CrossRef][Medline] [Order article via Infotrieve]
  • Van Horn L., Moag-Stahlberg A., Liu K., et al. Effect on serum lipids of adding instant oats to usual American diets. Am J Public Health. 1991;81:183-188.[Abstract/Free Full Text]
  • Johnston L., Reynolds HB, Hunninghake DB, Schultz K., Westereng B. Cholesterol-lowering benefits of a whole grain oat ready to eat cereal. Nutr Clin Care. 1998;1:6-12.[Medline] [Order article via Infotrieve]
  • Karmally JM, Montez MG Cholesterol-lowering benefits of oat-containing cereal in Hispanic Americans. J Am Diet Assoc. 2005;105:967-970.[CrossRef][Medline] [Order article via Infotrieve]
  • Keenan JM, Pins JJ, Frazel C., Moran A., Turnquist L. Oat ingestion reduces systolic and diastolic blood pressure in patients with mild to borderline hypertension: a pilot trial. J Fam Pract. 2002;51:369.[Medline] [Order article via Infotrieve]
  • Pins JJ, Geleva DRD, Keenan JM, Frazel C., O'Connor PJ, Cherney LM Do wholegrain oat cereals reduce the need for antihypertensive medications and improve blood pressure control? J Fam Pract. 2002;51:353-359.[Medline] [Order article via Infotrieve]
  • Reynolds HR, Quiter E., Hunninghake DB Whole grain oat cereal lowers serum lipids. Topics Clin Nutr. 2000;15:74-83.
  • The Lipids Research Clinics Coronary Primary Prevention Trial result. I. Reduction in incidence of coronary heart disease. JAMA. 1984;251:351-364.[Abstract/Free Full Text]
  • Katan M., Grundy SM, Jones P., Law M., Miettinen T., Paoletti R. Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels. Mayo Clin Proc. 2003;78:965-978.[Abstract/Free Full Text]
  • Grundy SM, Cleeman JI, Bairey Merz CN, et al. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation. 2004;110:227-239.[Abstract/Free Full Text]
  • Cohen JC, Boerwinkle E., Mosley TH Jr, Hobbs HH Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med. 2006;354:1264-1272.[Abstract/Free Full Text]
  • Brown MS, Goldstein JL Lowering LDL— not only how low, but how long? Science. 2006;311:1721-1723.[Abstract/Free Full Text]
  • Marlett JA, Hosig KB, Vollendorf NW, Shinnick FL, Haack VS, Story JA Mechanism of serum cholesterol reduction by oat bran. Hepatology. 1994;20:1450-1457.[CrossRef][Medline] [Order article via Infotrieve]
  • Lia A., Hallmans G., Sandberg AS, Sundberg G., Aman P., Andersson H. Oat beta-glucan increases bile acid secretion and a fiberrich barley fraction increases cholesterol excretion in ileostomy subjects. Am J Clin Nutr. 1995;622:1245-1251.
  • Andersson M., Ellegard L., Andersson H. Oat bran stimulates bile acid synthesis within an 8 h as measured by 7-alpha-hydroxy-4-cholesten-3-one. Am J Clin Nutr. 2002;76:1111-1116.[Abstract/Free Full Text]
  • Ellegard L., Andersson H. Oat bran rapidly increases bile acid excretion and bile acid synthesis: an ileostomy study. Eur J Clin Nutr. 2007;61:938-945.[CrossRef][Medline] [Order article via Infotrieve]
  • Ripsin CM, Keenan JM, Jacobs DR, et al. Oat products and lipid lowering: a meta-analysis. JAMA. 1992;267:3317-3325.[Abstract/Free Full Text]
  • Jenkins DJ, Wolever TM, Vuksan V., et al. Nibbling versus gorging: metabolic advantages of increased meal frequency. N Engl J Med. 1989;321:929-934.[Abstract]
  • Murphy MC, Chapman C., Lovegrove JA, et al. Meal frequency: does it determine postprandial lipaemia? Eur J Clin Nutr. 1996;50:491-497.[Medline] [Order article via Infotrieve]
  • Farshchi HR, Taylor MA, Macdonald IA Regular meal frequency creates more appropriate insulin sensitivity and lipid profiles compared with irregular meal frequency in healthy lean women. Eur J Clin Nutr. 2004;58:1071-1077.[CrossRef][Medline] [Order article via Infotrieve]
  • Anderson JW, Konz EC Obesity and disease management: effects of weight loss on co-morbid conditions. Obes Res. 2001;9:326S-334S.[Medline] [Order article via Infotrieve]
  • Saltzman E., Das SK, Lichtenstein AH, et al. An oat-containing hypocaloric diet reduces systolic blood pressure and improves lipid profile beyond effects of weight loss in men and women. J Nutr. 2001;131:1465-1470.[Abstract/Free Full Text]
  • Berg A., Konig D., Deibert P., et al. Effect of an oat bran enriched diet on the atherogenic lipid profile in patients with an increased coronary heart disease risk. Ann Nutr Metab. 2003;47:306-311.[CrossRef][Medline] [Order article via Infotrieve]
  • Otvos JD, Collins D., Freedman DS, et al. Low-density lipoprotein and high-density lipoprotein particle subclasses predict coronary events and are favorably altered by gemfibrozil therapy in the Veterans Affairs High-Density Lipoprotein Intervention Trial. Circulation. 2006;113:1556-1563.[Abstract/Free Full Text]
  • Davy BM, Davy KP, Ho RC, Beske SD, Davrath LR, Melby CL High-fiber oat cereal compared with wheat cereal consumption favorably alters LDL-cholesterol subclass and particle numbers in middle-aged and older men. Am J Clin Nutr. 2002;76:351-358.[Abstract/Free Full Text]
  • Chen Oc-Y, Milbury PE, Collins FW, Blumberg JB Avenanthramides are bioavailable and have antioxidant activity in humans after acute consumption of an enriched mixture from oats. J Nutr. 2007;137:1375-1382.[Abstract/Free Full Text]
  • Liu L., Zubik L., Collins FW, Marko M., Meydani M. The antiatherogenic potential of oat phenolic compounds. Atherosclerosis. 2004;175:39-49.[CrossRef][Medline] [Order article via Infotrieve]
  • Nie L., Wise ML, Peterson DM, Meydani M. Avenanthramide, a polyphenol from oats, inhibits vascular smooth muscle cell proliferation and enhances nitric oxide production. Atherosclerosis. 2006;186:260-266.[CrossRef][Medline] [Order article via Infotrieve]
  • Nie L., Wise M., Peterson D., Meydani M. Mechanism by which avenanthramide-c, a polyphenol of oats, blocks cell cycle progression in vascular smooth muscle cells. Free Radic Biol Med. 2006;41:702-708.[CrossRef][Medline] [Order article via Infotrieve]
  • Jacobs DR, Meyer KA, Kushi LH, Folsom AR Is whole grain intake associated with reduced total and cause-specific death rates in older women? The Iowa Women's Health Study. Am J Public Health. 1999;89:332-339.
  • McKeown NM, Meigs JB, Liu S., Wilson PWF, Jacques PF Whole-grain intake is favorably associated with metabolic risk factors for type 2 diabetes and cardiovascular disease in the Framingham Offspring Study. Am J Clin Nutr. 2002;76:390-398.[Abstract/Free Full Text]
  • Steffen LM, Jacobs DR Jr, Stevens J., Shahar E., Carithers T., Folsum AR Associations of whole-grain, refined grain, and fruit and vegetable consumption with risks of all-cause mortality and incident coronary artery disease and ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) Study. Am J Clin Nutr. 2003;78:383-390.[Abstract/Free Full Text]
  • Jabobs DR, Meyer KA, Kushi LH, Folsom AR Whole-grain intake may reduce the risk of ischemic heart disease in postmenopausal women: the Iowa Women's Health Study. Am J Clin Nutr. 1998;68:248-257.[Abstract]
  • Lui S., Stampfer MJ, Hu FB, et al. Wholegrain consumption and risk of coronary heart disease: results from the Nurses' Health Study. Am J Clin Nutr. 1999:70;412-419.[Abstract/Free Full Text]
  • Truswell AS Cereal grains and coronary heart disease. Eur J Clin Nutr. 2002;56:1-14.[CrossRef][Medline] [Order article via Infotrieve]
  • Liu S., Manson JE, Stampfer MJ, et al. Whole grain consumption and risk of ischemic stroke in women: a prospective study. JAMA. 2000;284:1534-1540.[Abstract/Free Full Text]
  • Liu S., Buring JE, Sesso HD, Rimm EB, Willett WC, Manson JE A prospective study of dietary fiber intake and risk of cardiovascular disease among women. J Am Coll Cardiol. 2002;39:49-56.[Abstract/Free Full Text]
  • Jensen MK, Koh-Banerjee P., Hu FB, et al. Intake of whole grains, bran and germ and risk of coronary heart disease among men. Am J Clin Nutr. 2004;80:1492-1499.[Abstract/Free Full Text]
  • Rimm EB, Ascherio A., Giovannucci E., Spiegelman D., Stampfer MJ, Willett WC Vegetable, fruit, and cereal fiber intake and risk of coronary heart disease among men. JAMA. 1996;275:447-451.[Abstract/Free Full Text]
  • Salmeron J., Ascherio A., Rimm EB, et al. Dietary fiber, glycemic load, and risk of NIDDM in men. Diabetes Care. 1997;20:545-550.[Abstract]
  • Salmeron J., Manson JE, Stampfer MJ, Colditz GA, Wing AL, Willett WC Dietary fiber, glycemic load, and risk of non-insulin-dependent diabetes mellitus in women. JAMA. 1997;277:472-477.[Abstract/Free Full Text]
  • Liu S., Manson JE, Stampfer MJ, et al. A prospective study of whole grain intake and risk of type 2 diabetes mellitus in US women. Am J Public Health. 2000;90:1409-1415.[Abstract/Free Full Text]
  • Meyer KA, Kushi LH, Jacobs DR, Slavin J., Sellers TA, Folsom AR Carbohydrates, dietary fiber, and incidence of type 2 diabetes in older women. Am J Clin Nutr. 2000;71:921-930.[Abstract/Free Full Text]
  • Fung TT, Hu FB, Pereira MA, et al. Wholegrain intake and risk of type 2 diabetes: a prospective study in men. Am J Clin Nutr. 2002;76:535-540.[Abstract/Free Full Text]
  • Hodge AM, English DR, O'Dea K, Giles GG. Glycemic index and dietary fiber and the risk of type 2 diabetes. Diabetes Care. 2004;27:2701-2706.[Abstract/Free Full Text]
  • Montonen J., Knekt P., Jarvinen R., Aromaa A., Reunanen A. Whole-grain and fiber intake and the incidence of type 2 diabetes. Am J Clin Nutr. 2003;77:622-629.[Abstract/Free Full Text]
  • Murtaugh MA, Jacobs DR, Jacob B., Steffen LM, Marquart L. Epidemiological support for the protection of whole grains against diabetes. Proc Nutr Soc. 2003;62:143-149.[CrossRef][Medline] [Order article via Infotrieve]
  • Steffen LM, Jacobs DR, Murtaugh MA, et al. Whole-grain intake is associated with lower body mass and greater insulin sensitivity among adolescents. Am J Epidemiol. 2003;158:243-250.[Abstract/Free Full Text]
  • Liu S., Willett WC, Manson JE, Hu FB, Rosner B., Colditz G. Relation between changes in intakes of dietary fiber and grain products and changes in weight and development of obesity among middle-aged women. Am J Clin Nutr. 2003;78:920-927.[Abstract/Free Full Text]
  • Koh-Banergee P., Franz M., Sampson L., et al. Changes in whole-grain, bran, and cereal fiber consumption in relation to 8-y weight gain among men. Am J Clin Nutr. 2004;80:1237-1245.[Abstract/Free Full Text]
  • Koh-Banergee P., Rimm EB Whole grain consumption and weight gain: a review of the epidemiological evidence, potential mechanisms and opportunities for future research. Proc Nutr Soc. 2003;62:25-29.[CrossRef][Medline] [Order article via Infotrieve]
  • Slavin J. Why whole grains are protective: biological mechanisms. Proc Nutr Soc. 2003;62:129-134.[CrossRef][Medline] [Order article via Infotrieve]
  • Slavin J. Whole grains and human health. Nutr Res Rev. 2004;17:99-110.[CrossRef][Medline] [Order article via Infotrieve]
  • US Food and Drug and Administration, Center for Food Safety and Applied Nutrition, Office of Food Labeling. Health claim notification for whole grains. July 1999. http://www.cfsan.fda.gov/~dms/flgrains.html. Accessed July 16, 2007.
  • Svetkey LP, Simons-Morton D., Vollmer WM, et al. Effects of dietary patterns on blood pressure: subgroup analysis of the Dietary Approaches to Stop Hypertension (DASH) randomized clinical trial. Arch Intern Med. 1999;159:285-293.[Abstract/Free Full Text]
  • US Department of Health and Human Services and US Department of Agriculture. Dietary Guidelines for Americans, 2005. 6th ed. Washington, DC: Government Printing Office; 2005.
  • Azadbakht L., Mirmiran P., Esmaillzadeh A., Azizi T., Azizi F. Beneficial effects of a Dietary Approaches to Stop Hypertension eating plan on features of the metabolic syndrome. Diabetes Care. 2005;28:2823-2831.[Abstract/Free Full Text]
  • Lin P-H., Aickin M., Champagne C., et al. Food group sources of nutrients in the dietary patterns of the DASH-sodium trial. J Am Diet Assoc. 2003;103:488-496.[Medline] [Order article via Infotrieve]
  • Carlson A., Mancino L., Lino M. Nutrition insight 32: grain consumption by Americans. 2005. US Department of Agriculture, Center for Nutrition Policy and Promotion. http://www.cnpp.usda.gov. Accessed July 6, 2007.
  • Maki KC, Galant R., Samuel P., et al. Effects of consuming foods containing oat β-glucan on blood pressure, carbohydrate metabolism and biomarkers of oxidative stress in men and women with elevated blood pressure. Eur J Clin Nutr. 2007;61:786-795.[CrossRef][Medline] [Order article via Infotrieve]
  • Davy BM, Melby CL, Beske SD, Ho RC, Davrath LR, Davy KP Oat consumption does not affect resting casual and ambulatory 24-h arterial blood pressure in men with high-normal blood pressure to stage I hypertension. J Nutr. 2002;132:394-398.[Abstract/Free Full Text]
  • He J., Streiffer RH, Muntner P., Krousel-Wood MA, Whelton PK Effect of dietary fiber intake on blood pressure: a randomized, double-blind, placebo-controlled trial. J Hypertens. 2004;22:73-80.[CrossRef][Medline] [Order article via Infotrieve]
  • The Report of the Dietary Guidelines Advisory Committee on Dietary Guidelines for Americans, 2005. Department of Health and Human Services. http://www.health.gov/dietaryguidelines. Accessed on July 7, 2007.
  • American Diabetes Association. Nutrition recommendations and interventions for diabetes—2006: a position statement of the American Diabetes Association. Diabetes Care. 2006;29:2140-2157.[Free Full Text]
  • Pereira MA, Jacobs DRJ, Slattery M., et al. The association of whole grain intake and fasting insulin in a biracial cohort of young adults: the CAARDIA study. Cardiovasc Dis Prev. 1998;1:231-242.
  • Pereira MA, Jacobs DR, Van Horn L., et al. Dairy consumption, obesity, and the insulin resistance syndrome in young adults. The CARDIA Study. JAMA. 2002;287:2081-2089.[Abstract/Free Full Text]
  • Pereira MA, Jacobs DR, Pins JJ, et al. Effect of whole grains on insulin sensitivity in overweight hyperinsulinemic adults. Am J Clin Nutr. 2002;75:848-855.[Abstract/Free Full Text]
  • Food and Nutrition Board, Institute of Medicine of the National Academies. Dietary Reference Intakes for Energy, Carbohydrates, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (Macronutrients). Washington, DC: National Academies Press; 2005.
  • Resource guide for nutrition and physical activity interventions to prevent obesity and other chronic disease. Nutrition, Physical Activity, and Obesity Prevention Program, Centers for Disease Control and Prevention, Department of Health and Human Services. http://www.cdc.gov. Accessed July 8, 2007.
  • Slavin JL Dietary fiber and body weight. Nutrition. 2005;21:411-418.[CrossRef][Medline] [Order article via Infotrieve]
  • Joint WHO/FAO Expert Consultation on Diet, Nutrition and the Prevention of Chronic Diseases. WHO Technical Report Series 916. Geneva, Switzerland: World Health Organization; 2003.
  • Holt SE, Brand Miller JC, Farmakalidis E. A satiety index of common foods. Eur J Clin Nutr. 1995;49:675-690.[Medline] [Order article via Infotrieve]
  • Rolls BJ, Bell EA, Thorwart ML Water incorporated into a food but not served with a food decreases energy intake in lean women. Am J Clin Nutr. 1999;70:448-455.[Abstract/Free Full Text]
  • US Department of Agriculture, Economic Research Service. Food availability (per capita) data system/loss adjusted food available. http://www.ers.usda.gov. Accessed July 8, 2007.

American Journal of Lifestyle Medicine, Vol. 2, No. 1, 51-57 (2008)
DOI: 10.1177/1559827607309130.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
Nutr Clin PractHome page
V. S. Retelny, A. Neuendorf, and J. L. Roth
Nutrition Protocols for the Prevention of Cardiovascular Disease
Nutr Clin Pract, October 1, 2008; 23(5): 468 - 476.
[Abstract] [Full Text] [PDF]


This Article
Right arrow Abstract Freely available
Right arrow Free Full Text (Free PDF) Free
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Andon, M. B.
Right arrow Articles by Anderson, J. W.
Right arrow Search for Related Content
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Advertisement